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A little tension keeps us on our toes. In fact, a certain level of stress is fundamental when it comes to living a full and meaningful life. Some might argue being stressed about something shows that we care,[1][2] while the World Health Organisation affirms that stress connects us directly with the most challenging and important aspects of our lives.[3] Stress can come from our environment, from our bodies, or even our own thoughts and how we view the world around us, and has become a common issue of modern life.[4]
Did you know: Stress can cause depletion of micronutrients such as magnesium, zinc, calcium, iron, and niacin from our body – all of which are essential for our optimal physical and mental function.[5]
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Any internal or external stimulus that evokes a physiological response is known as stress[6], while it can also arise from any event or any thought that may bring about frustration, anger, or nerves.[7][8]
While it can be triggered by different life experiences, and everyone is stressed by different things, common external causes of stress include:
Biologically, stress is our body's natural defence against predators and danger, and we are physiologically designed to deal with, and react to it.[10]
While we all deal with stress differently, our ability to cope can depend on our genetics, early life events, our personality and our social or economic circumstances.[11] It can even depend on the lifestyle we lead and the quality of our diet on a day-to-day basis, as certain nutrients can provide us with the extra energy we need to cope with stressful events.[12] An increasing number of studies reveal that diet and nutrition are critical not only for physiology and body composition, but also play a significant role in supporting our cognition and our stress adaption.[13]
The two main classifications of stress are:
Did you know? Stress can also be positive, as the stress response help us stay alert, motivated and focused on the task at hand. This type of stress also has its own classification, known as “eustress”. Generally eustress will bring with it motivation to complete a task series of tasks that take us out of our comfort zone.[17]
We react to stress via physiological changes our bodies undergo when we are under stress. General adaptation syndrome (GAS)[18] is the three-stage stress adaptation process incorporating:
When we perceive stress, our adrenal glands make and release the hormone cortisol into our bloodstream. Often called the “stress hormone,” when cortisol is released, it is done so alongside epinephrine (also known as adrenaline) and noradrenaline via a series of complex physiological reactions. It is essentially our natural “flight or fight” response which has kept humans alive for thousands of years.[21]
Stress affects all systems of the body including the musculoskeletal, respiratory, cardiovascular, endocrine, gastrointestinal, nervous, and reproductive systems.[22]
Environmental factors that trigger this reaction are called “stressors”. Examples include loud noises, aggressive behaviour, a traffic accident or speeding car, tight work deadlines, or even going out on a first date. Feelings of stress tend to increase in tandem with the number of stressors.
There are three parts of the brain that are highly involved in how we recognise and respond to stressors:
The amygdala is involved in the processing of emotions, including fear and the perception of threat, along with initiation of our "fight or flight" response. When the amygdala perceives a threat, it signals the hypothalamus. The hypothalamus then signals our adrenal glands in the kidneys via our HPA axis to release hormones like epinephrine (aka adrenaline) and the stress hormone cortisol into our bloodstream. The role of cortisol is essentially to keep our body on high alert, while also increasing immune system and memory functions.[24]
Once the threat is resolved and the brain no longer perceives danger, cortisol and epinephrine levels reduce to baseline levels.
The hippocampus plays an integral role in the formation, organisation, and storage of new memories and in connecting certain sensations and emotions to these memories. It also plays an important part in the emotional memory recall.[25]
Acute stress can cause an imbalance of neural circuitry, hindering cognitive processes such as decision making, and negatively impacting our mood leading to a heightened state of anxiety.[26]
Long-term chronic stress however, can compromise or even damage the hippocampus, so finding ways to manage stress may help protect this part of our brain.[27]
Our prefrontal cortex makes up over 10% of the volume of the brain, serving as its control centre, mediating our executive functions that allow us to concentrate, plan, make decisions, evaluate risks, and even retrieve memories.[29] It controls the emotional responses to stress by regulating the amygdala[30], and can even shut down when stress becomes too much - inducing mental paralysis and panic.29
Epinephrine (adrenaline) release leads to physiological changes in the body. The heart starts beating faster, pumping more blood through the body’s muscles and vital organs. The breath also becomes more rapid, and little blood vessels in the lungs open up to allow the lungs to work more efficiently. Extra oxygen is then sent to the brain, increasing alertness.[31][32]
Epinephrine also causes sugar and fats to be released from storage and this increases the amount of energy available to the body.[33]
The production of epinephrine, norepinephrine and cortisol combined can in fact bring about a range of physiological symptoms which can include:
1. https://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol33_noSuppl%204/dnb_vol33_noSuppl%204_1025.pdf
2. https://hbr.org/2015/09/stress-can-be-a-good-thing-if-you-know-how-to-use-it
3. https://www.who.int/news-room/questions-and-answers/item/stress
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/
5. https://pubmed.ncbi.nlm.nih.gov/31504084/
6. https://ncbi.nlm.nih.gov/pmc/articles/PMC5579396/
7. https://medlineplus.gov/ency/article/003211.htm
8. https://www.webmd.com/mental-health/signs-frustration
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323923/
10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964013/
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699555/
12. https://www.hsph.harvard.edu/nutritionsource/stress-and-health/
13. https://pubmed.ncbi.nlm.nih.gov/33763446/
14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137920/
15. https://medlineplus.gov/ency/article/003211.htm
16. https://pubmed.ncbi.nlm.nih.gov/37603622/
17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872528/
18. https://www.ncbi.nlm.nih.gov/books/NBK541120/
19. https://www.tandfonline.com/doi/full/10.1080/1744666X.2022.2052045
20. https://www.healthline.com/health/general-adaptation-syndrome
21. https://pubmed.ncbi.nlm.nih.gov/31249398/
22. https://www.ncbi.nlm.nih.gov/books/NBK541120/
23. https://pubmed.ncbi.nlm.nih.gov/26076834/
24. https://www.imrpress.com/journal/JMCM/3/3/10.31083/j.jmcm.2020.03.806
25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789138/
26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573220/
27. https://www.verywellmind.com/what-is-the-hippocampus-2795231
28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561403/
29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774859/
30. https://kids.frontiersin.org/articles/10.3389/frym.2017.00071
31. https://www.ncbi.nlm.nih.gov/books/NBK482160/
32. https://my.clevelandclinic.org/health/articles/22611-epinephrine-adrenaline
33. https://www.ncbi.nlm.nih.gov/books/NBK545201/
34. https://www.mind.org.uk/information-support/types-of-mental-health-problems/stress/signs-and-symptoms-of-stress/
35. https://my.clevelandclinic.org/health/articles/11874-stress
36. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353523/
37. https://www.mentalhealth.org.uk/explore-mental-health/a-z-topics/stress
38. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921311/
39. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441951/
40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744869/
41. https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/exercise-and-stress/art-20044469
42. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863117/
43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647439/
44. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036360/
45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482966/
46.https://www.researchgate.net/publication/346655291_Magnesium_Status_and_Stress_The_Vicious_Circle_Concept_Revisited
47. https://pubmed.ncbi.nlm.nih.gov/31527485/
48. https://pubmed.ncbi.nlm.nih.gov/32745879/
49. https://pubmed.ncbi.nlm.nih.gov/34476568/
50. https://pubmed.ncbi.nlm.nih.gov/32148930/
51. https://www.hsph.harvard.edu/nutritionsource/vitamin-c/
52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
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54.https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.R4220